New CRISPR proteins expand editing access to heart disease genes

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Health & Medicine United Kingdom

Rice University's Han Xiao has used his AI-supported Sequence Display technology to expand the targeting abilities of CRISPR/Cas9. In a paper recently published in Nature Communications, Xiao evolved several variants of a compact Cas9 that could efficiently target stretches of DNA previously inaccessible for editing. The research included a proof-of-concept study in which the evolved Cas9s were…

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