Case Report: Hyperactive delirium with psychotic symptoms associated with severe hypothyroidism during pembrolizumab therapy. Complete remission after levothyroxine and no recurrence after pembrolizumab rechallenge
Thyroid dysfunction is a common adverse event during pembrolizumab therapy, but severe hypothyroidism accompanied by acute neuropsychiatric symptoms is rare. We present the case of a 78-year-old woman with metastatic colorectal cancer who developed agitation, hallucinations, and confusion three months after initiation of Pembrolizumab. Evaluation revealed profound hypothyroidism (TSH 37.9 mU/L,…
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