Extracellular vesicle miRNAs, NOS/NO homeostasis, and NLRP3 inflammasome signaling in schizophrenia-related cognitive impairment: a mechanistic review and testable hypothesis

Frontiers in Psychiatry | New and Recent Articles ·
Mind & Mental Health Switzerland

Cognitive impairment is a major determinant of poor functional recovery in schizophrenia, but the molecular events connecting neuroimmune disturbance, redox imbalance, and synaptic dysfunction remain incompletely understood. Studies in patients have reported altered extracellular vesicle microRNA (EV-miRNA) profiles, abnormalities in nitric oxide synthase/nitric oxide (NOS/NO)-related markers,…

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