Copenhagen Magnetic Personalized Accelerated Brain Circuit Therapy (CoMPACT) trial: study protocol for a randomized, double-blinded, sham-controlled, three-armed, parallel-group trial of transcranial magnetic stimulation for treatment-resistant depression

Frontiers in Psychiatry | New and Recent Articles ·
Mind & Mental Health Switzerland

BackgroundTreatment-resistant depression (TRD), characterized by poor response to conventional antidepressant therapies, remains a major clinical challenge. Repetitive transcranial magnetic stimulation (TMS) of the left dorsolateral prefrontal cortex (dlPFC) has emerged as a promising alternative. Employing intermittent theta burst stimulation (iTBS), TMS protocols have yielded rapid…

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