Faulty cellular recycling may link pulmonary arterial hypertension to brain damage
A commentary in The Journal of Clinical Investigation examines evidence linking pulmonary arterial hypertension (PAH) to cerebellar abnormalities, focusing on impaired lysosomal lipid metabolism, oxysterol accumulation, and microglial inflammation. Findings from human imaging, mouse models, and cultured cells suggest that NCOA7 may help protect against these changes, although the proposed…
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