Metabolic and inflammatory traits and depression: a Mendelian randomization study with late-adolescent population-based and clinical triangulation
ObjectiveMetabolic dysfunction and systemic inflammation have been associated with adolescent depression, but their causal relevance remains uncertain. We examined whether insulin resistance, proxied by the triglyceride-glucose (TyG) index, and high-sensitivity C-reactive protein (hs-CRP) show genetically proxied associations with major depressive disorder (MDD), and evaluated their observational…
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